Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential
for the development of committed erythroid progenitor cells beyond the colony-forming unit …

Human 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is a key steroidogenic
enzyme that catalyzes the first step in the conversion of circulating dehydroepiandrosterone …

The K562 erythroleukemia cell line was used to study the molecular mechanisms regulating
lineage commitment of hematopoietic stem cells. Phorbol esters, which initiate …

Background: Pancreatic stellate cells (PSCs) have been implicated in pancreatic fibrosis as
they synthesise increased amounts of extracellular matrix proteins in response to activation …

In multiple sclerosis (MS), long-term disability is primarily caused by axonal and neuronal
damage. We demonstrated in a previous study that neuronal apoptosis occurs early during …

Erythropoietin (Epo) is a hematopoietic factor that facilitates erythroid progenitor cell
proliferation and differentiation. Recently, trophic effects of Epo have been observed in …

Although considered tightly linked, the linkage effectors for proliferation and antiapoptotic
signaling pathways are not clear. Phosphorylation of Bcl2 at serine 70 is required for …

Objective: Recent studies suggested that erythropoietin (Epo) receptors (EpoR) are
expressed not only in the hematopoietic lineage cells but also in the heart and that the …

Neutrophils play a vital role in the immune defense, which is evident by the severity of
neutropenia causing life-threatening infections. Granulocyte macrophage-colony stimulating …

Background: Urothelial carcinoma (UC) commonly occurs in the urinary bladder (UB) and
rarely in upper the upper urinary tract (UT). Its molecular pathogenesis, however, remains …