Almost all biomedical research to date has relied upon mean measurements from cell
populations, however it is well established that what it is observed at this macroscopic level …

Network pharmacology (NP) provides a new methodological perspective for understanding
traditional medicine from a holistic perspective, giving rise to frontiers such as traditional …

Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …

Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their
migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an …

Background The precise characterization of individual tumors and immune
microenvironments using transcriptome sequencing has provided a great opportunity for …

Legume-rhizobium signaling during establishment of symbiotic nitrogen fixation restricts
rhizobium colonization to specific cells. A limited number of root hair cells allow infection …

Rare cells have an important role in development and disease, and methods for isolating
and studying cell subsets are therefore an essential part of biology research. Such methods …

Bladder carcinoma (BC) recurrence is a major clinical challenge, and targeting the tumor
microenvironment (TME) is a promising therapy. However, the relationship between …

Background Aging is an influential risk factor for progression of both degenerative and
oncological diseases of the bone. Osteosarcoma, considered the most common primary …

Cellular heterogeneity is prevalent in all cell populations. Single-cell analysis (SCA) could
unveil the heterogeneity and thus gain unique insights into complex biological processes …