The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Interindividual variability in drug disposition is a major cause of lack of efficacy and adverse
effects of drug therapies. The majority of hepatically cleared drugs are metabolized by …

Background Persistent postoperative pain (PPP) is common after total knee arthroplasty
(TKA). The primary aim of this prospective cohort study was to identify important predictors of …

Aims Patients on treatment with oral fixed dose imatinib are frequently under‐or
overexposed to the drug. We investigated the association between the gene activity score …

Aims This study implements a physiologically‐based pharmacokinetic (PBPK) modelling
approach to investigate inter‐ethnic differences in imatinib pharmacokinetics and dosing …

Masitinib is a small molecule tyrosine kinase inhibitor under investigation for the treatment of
amyotrophic lateral sclerosis, mastocytosis, and COVID-19. Hepatotoxicity has been …

In children and adolescents, impaired growth due to tyrosine kinase inhibitor therapy
remains an insufficiently studied adverse effect. This study examines demographic …

We aimed to use physiologically based pharmacokinetic (PBPK) modeling and simulation to
predict imatinib steady‐state plasma exposure in patients with chronic myeloid leukemia …

Tyrosine kinase inhibitors (TKI) have revolutionized the treatment of chronic myeloid
leukemia (CML), but patients still experience treatment‐limiting toxicities or therapeutic …

Background Bladder cancer is the most common leading cause of mortality around the
world. Previous studies have indicated that genetic factors are significantly associated with …