[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …
in a non-disruptive and non-invasive manner. The obtained molecular properties at …
Crystal polymorphism in chemical process development
AY Lee, D Erdemir, AS Myerson - Annual review of chemical …, 2011 - annualreviews.org
Polymorphism in molecular crystals is a prevalent phenomenon and is of great interest to the
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …
An overview of recent studies on the analysis of pharmaceutical polymorphs
Pharmaceutical solids are well known to be able to exist in different solid-state forms and
there are a wide variety of solid-state analytical techniques available to characterize …
there are a wide variety of solid-state analytical techniques available to characterize …
Effects of crystal form on solubility and pharmacokinetics: a crystal engineering case study of lamotrigine
In this contribution, we describe how the supramolecular synthon approach can be used for
discovery of novel crystal forms and for enhancing the relevant preclinical properties of a low …
discovery of novel crystal forms and for enhancing the relevant preclinical properties of a low …
Structure− stability relationships in cocrystal hydrates: Does the promiscuity of water make crystalline hydrates the nemesis of crystal engineering?
This contribution addresses the role of water molecules in crystal engineering by studying
the crystal structures and thermal stabilities of 11 new cocrystal hydrates, all of which were …
the crystal structures and thermal stabilities of 11 new cocrystal hydrates, all of which were …
Machine learning accelerates quantum mechanics predictions of molecular crystals
Quantum mechanics (QM) approaches (DFT, MP2, CCSD (T), etc.) play an important role in
calculating molecules and crystals with a high accuracy and acceptable efficiency. In recent …
calculating molecules and crystals with a high accuracy and acceptable efficiency. In recent …
NMR studies of organic polymorphs & solvates
RK Harris - Analyst, 2006 - pubs.rsc.org
This review article describes the applications of NMR to the study of polymorphs and related
forms (solvates) of organic (especially pharmaceutical) compounds, for which it is of …
forms (solvates) of organic (especially pharmaceutical) compounds, for which it is of …
Solid‐state NMR studies of pharmaceutical systems
M Geppi, G Mollica, S Borsacchi… - Applied Spectroscopy …, 2008 - Taylor & Francis
High‐and low‐resolution solid‐state nuclear magnetic resonance (SSNMR) applications to
the study of pharmaceuticals are reviewed. Examples are shown involving the use of mono …
the study of pharmaceuticals are reviewed. Examples are shown involving the use of mono …
Cocrystals, salts, and salt-solvates of olanzapine; selection of coformers and improved solubility
Pharmaceutical cocrystals and salts are extensively researched in recent years due to their
ability to tune the physicochemical properties of active pharmaceutical ingredients (APIs). A …
ability to tune the physicochemical properties of active pharmaceutical ingredients (APIs). A …
Pharmaceutical cocrystals of niclosamide
Niclosamide (NCL) is an anthelmintic BCS class II drug of low solubility and high
permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such …
permeability. Pharmaceutical cocrystals of NCL were prepared with GRAS molecules, such …