Regulation and metabolic functions of mTORC1 and mTORC2

A Szwed, E Kim, E Jacinto - Physiological reviews, 2021 - journals.physiology.org
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

MYCN function in neuroblastoma development

J Otte, C Dyberg, A Pepich, JI Johnsen - Frontiers in oncology, 2021 - frontiersin.org
Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Müller glia-mediated retinal regeneration

H Gao, X Huang, XI Chen, H Xu - Molecular neurobiology, 2021 - Springer
Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …

Systems biology and metabolic modeling for cultivated meat: A promising approach for cell culture media optimization and cost reduction

S Gomez Romero, N Boyle - … in Food Science and Food Safety, 2023 - Wiley Online Library
The cultivated meat industry, also known as cell‐based meat, cultured meat, lab‐grown
meat, or meat alternatives, is a growing field that aims to generate animal tissues ex‐vivo in …

The inositol phosphate system—A coordinator of metabolic adaptability

B Tu-Sekine, SF Kim - International journal of molecular sciences, 2022 - mdpi.com
All cells rely on nutrients to supply energy and carbon building blocks to support cellular
processes. Over time, eukaryotes have developed increasingly complex systems to integrate …

Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts

AM Kozlov, A Lone, DH Betts, RC Cumming - Scientific reports, 2020 - nature.com
Recent evidence has emerged that cancer cells can use various metabolites as fuel
sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote …

A human stem cell-derived brain-liver chip for assessing blood-brain-barrier permeation of pharmaceutical drugs

L Koenig, AP Ramme, D Faust, M Mayer, T Flötke… - Cells, 2022 - mdpi.com
Significant advancements in the field of preclinical in vitro blood-brain barrier (BBB) models
have been achieved in recent years, by developing monolayer-based culture systems …

Insights on the regeneration potential of Müller glia in the mammalian retina

A Salman, ME McClements, RE MacLaren - Cells, 2021 - mdpi.com
Müller glia, the major glial cell types in the retina, maintain retinal homeostasis and provide
structural support to retinal photoreceptors. They also possess regenerative potential that …

The key role of mitochondria in somatic stem cell differentiation: From mitochondrial asymmetric apportioning to cell fate

I Amato, S Meurant, P Renard - International Journal of Molecular …, 2023 - mdpi.com
The study of the mechanisms underlying stem cell differentiation is under intensive research
and includes the contribution of a metabolic switch from glycolytic to oxidative metabolism …

Targeting the redox system for cardiovascular regeneration in aging

MS Allemann, P Lee, JH Beer, SS Saeedi Saravi - Aging Cell, 2023 - Wiley Online Library
Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …