Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic
connections within visual cortex determine the timing of the critical period for rewiring ocular …

Post-injury epilepsy (PIE) is a common complication following brain insults, including
ischemic, and traumatic brain injuries. At present, there are no means to identify the patients …

Alzheimer9s disease (AD) is characterized by progressive cognitive decline, increasingly
attributed to neuronal dysfunction induced by amyloid-β oligomers (AβOs). Although the …

Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is
unknown. Several molecular targets of lithium have been identified, but these putative …

Assembly of synapses requires proper coordination between pre-and postsynaptic
elements. Identification of cellular and molecular events in synapse formation and …

Asrocytic responses constitute one of the earliest and most prominent changes in the CNS
following ischemic injury. Astrocytes are known to carry out critical functions such as …

Objective—In calcific aortic valve disease, myofibroblasts and activation of the transforming
growth factor-β1 (TGF-β1) and Wnt/β-catenin pathways are observed in the fibrosa, the stiffer …

Thrombospondins (TSPs) are a family of large, oligomeric multidomain glycoproteins that
participate in a variety of biological functions as part of the extracellular matrix (ECM) …