Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Aim To update recommendations based on current best evidence concerning the treatment
of rheumatoid arthritis (RA), focusing particularly on the role of targeted therapies, to inform …

Janus kinase inhibitors (JAKi) belong to a new class of oral targeted disease-modifying
drugs which have recently revolutionized the therapeutic panorama of rheumatoid arthritis …

In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of
ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC …

Objective To evaluate whether biologic disease‐modifying antirheumatic drugs (DMARD s)
decrease cardiovascular disease (CVD) risk in rheumatoid arthritis (RA) and whether …

Inflammation has long been accepted as a key component of carcinogenesis. During
inflammation, inflammasomes are potent contributors to the activation of inflammatory …

Die frühzeitige Behandlung der rheumatoiden Arthritis (RA) ist von zentraler Bedeutung für
den gesamten weiteren Krankheitsverlauf. Das Ziel der Leitlinie ist, die Versorgung der …

For some patients with SARS-CoV-2, the worst clinical damage is not caused by the virus
itself, but by an overactive inflammatory state. In fact, in some people the immune system …

Postoperative ileus, which develops after each abdominal surgical procedure, is an
iatrogenic disorder characterized by a transient inhibition of gastrointestinal motility. Its …