The most practical synthetic routes to the preparation of as important pharmaceuticals as
oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid …

6, 14-ethenomorphinans are semisynthetic opiate derivatives containing an ethylene bridge
between positions 6 and 14 in ring-C of the morphine skeleton that imparts a rigid molecular …

A cascade reaction of thioamides with 6β-bromoandrostenedione in hexafluoroisopropanol
formed substituted thiazolo-androstenones. This is a simple and mild protocol to synthesize …

We have presented the synthesis of novel thiazolo‐and isothiazolo‐apomorphines 12–17
resulting–in part–from an unexpected isomerization step occurred during the acid‐catalyzed …

The synthesis of 4 H-thiochromene derivatives of apomorphines, a novel class of
isoquinoline alkaloid-related compounds, has been achieved by different O-dealkylation …

A novel strategy has been developed for the synthesis of ring A fused thiazolomorphinans
and ring D fused thiazoloaporphines offering the possibility of formation of regioisomeric …

Three independent strategies have been established for the synthesis of morphinans with
oxazole moieties derived from the aminophenol function of 2-aminomorphine. All the …

Abstract Morphine (1) and codeine (2) are two representatives of medically important,
frequently used natural opiates, therefore the exploration of their metabolic pathways and …

A simple synthesis of ring‐constrained endoethenomorphinans possessing 2′‐substituted
thiazole ring 4–6 has been achieved by regio‐and stereoselective Diels–Alder reaction of …

The synthesis and acid-catalyzed rearrangement of novel thiazolomorphinandienes have
been presented. An isomerization was observed simultaneously with the backbone …