Tumor-associated carbohydrate antigens (TACA) result from the aberrant glycosylation that
is seen with transformation to a tumor cell. The carbohydrate antigens that have been found …

Mucin-type O-glycans are found on mucins as well as many other glycoproteins. The
initiation step in synthesis is catalyzed by a large family of polypeptide GalNAc-transferases …

Abstract The Tn antigen (GalNAc α-O-Ser/Thr) is heterogeneously synthesized by a variety
of tumors and contains an epitope defined by lectins and antibodies as a cluster of αGalNAc …

A novel anticancer vaccine candidate built on a nonpeptidic scaffold has been synthesized.
Four S-Tn tumor-associated glycomimetic antigens have been clustered onto a calix [4] …

Colorectal adenocarcinomas arise from luminal lining epithelium of the colorectal tract which
is covered with highly glycosylated mucins. Mucin O-glycosylation is initiated by a family of …

Introduction: Carbohydrates are key participants in many biological processes including
reproduction, inflammation, signal transmission and infection. Their biocompatibility and …

Malignant transformation of epithelial cells is frequently associated with the alteration of
glycosylation pathways. Tn is a common tumor-associated carbohydrate antigen present in …

The Tn antigen (α-GalNAc-O-Ser/Thr) is one of the most specific human cancer-associated
structures. This antigen, together with mucins, the major carriers of O-glycosylated tumor …

Glycopeptide dendrimers containing different types of tumor associated‐carbohydrate
antigens (TN, TF, sialyl‐TN, sialyl‐TF, sialyl‐Lex, sialyl‐Lea etc.) were used in diagnosis and …

In vivo targeting of C-type lectin receptors is an effective strategy for increasing antigen
uptake and presentation by dendritic cells (DCs). To induce efficient immune response …