Nanofluidics: a new arena for materials science

Y Xu - Advanced Materials, 2018 - Wiley Online Library
A significant growth of research in nanofluidics is achieved over the past decade, but the
field is still facing considerable challenges toward the transition from the current physics …

DNA in nanochannels: theory and applications

K Frykholm, V Müller, KK Sriram… - Quarterly Reviews of …, 2022 - cambridge.org
Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

Nanofluidics for chemical and biological dynamics in solution at the single molecular level

N Chantipmanee, Y Xu - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Studying dynamics at the single-molecule level enables deeper and more detailed insights
into the behaviors, functions, mechanisms, and heterogeneity of chemical or biological …

Backfolding of wormlike chains confined in nanochannels

A Muralidhar, DR Tree, KD Dorfman - Macromolecules, 2014 - ACS Publications
Using pruned-enriched Rosenbluth method (PERM) simulations of a discrete wormlike
chain model, we provide compelling evidence in support of Odijk's prediction of two distinct …

Probing protein–DNA interactions and compaction in nanochannels

R Riehn - Current Opinion in Structural Biology, 2024 - Elsevier
DNA confined to nanofluidic channels with a cross-section from tens to hundreds of nm wide
and hundreds of microns long stretches in an equilibrium process free of flow or end …

Nanofluidics for sub-single cellular studies: Nascent progress, critical technologies, and future perspectives

J Yang, Y Xu - Chinese Chemical Letters, 2022 - Elsevier
In the field of cell studies, there is a burgeoning trend to further downscale the investigation
from a single-cell level to a sub-single-cell level. Subcellular matter is the basic content in …

Nanoconfined circular and linear DNA: Equilibrium conformations and unfolding kinetics

M Alizadehheidari, E Werner, C Noble… - …, 2015 - ACS Publications
Studies of circular DNA confined to nanofluidic channels are relevant both from a
fundamental polymer-physics perspective and due to the importance of circular DNA …

Experimental evidence of weak excluded volume effects for nanochannel confined DNA

D Gupta, JJ Miller, A Muralidhar, S Mahshid… - ACS macro …, 2015 - ACS Publications
We present experimental demonstration that weak excluded volume effects arise in DNA
nanochannel confinement. In particular, by performing measurements of the variance in …

A nanofluidic device for real-time visualization of DNA–protein interactions on the single DNA molecule level

R Öz, KK Sriram, F Westerlund - Nanoscale, 2019 - pubs.rsc.org
Single DNA molecule techniques have revolutionized our understanding of DNA–protein
interactions. Traditional techniques for such studies have the major drawback that the DNA …

Alpha‐synuclein modulates the physical properties of DNA

K Jiang, S Rocha, A Westling… - … A European Journal, 2018 - Wiley Online Library
Fundamental research on Parkinson's disease (PD) most often focuses on the ability of α‐
synuclein (aS) to form oligomers and amyloids, and how such species promote brain cell …