Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs
and maintain an individual's health. The liver has a major role in the control of glucose …

BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …

Salvia miltiorrhiza Bunge (SM) is a very popular medicinal plant that has been extensively
applied for many years to treat various diseases, especially coronary heart diseases and …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response
to a wide variety of signals, yet target gene transcription is only increased in a subset of …

Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal
mitochondrial function is ensured by a quality-control system tightly coupled to fusion and …

CREB is a transcription factor that regulates diverse cellular responses, including
proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and …

When energy supply is low, organisms respond by slowing aging and increasing resistance
to diverse age-related pathologies. Targeting the mechanisms underpinning this response …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …