Polyphenols: A first evidence in the synergism and bioactivities

S Mitra, AM Tareq, R Das, TB Emran… - Food Reviews …, 2023 - Taylor & Francis
Polyphenols are natural compounds and the most plentiful with synergistic properties
contributing to potential health benefits. This review describes the synergistic interactions of …

Therapeutic potential of PPARγ natural agonists in liver diseases

L Wu, C Guo, J Wu - Journal of cellular and molecular …, 2020 - Wiley Online Library
Peroxisome proliferator‐activated receptor gamma (PPARγ) is a vital subtype of the PPAR
family. The biological functions are complex and diverse. PPARγ plays a significant role in …

An alternate binding site for PPARγ ligands

TS Hughes, PK Giri, IMS De Vera, DP Marciano… - Nature …, 2014 - nature.com
PPARγ is a target for insulin-sensitizing drugs such as glitazones, which improve plasma
glucose maintenance in patients with diabetes. Synthetic ligands have been designed to …

Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system

J Lee, DG Jo, D Park, HY Chung, MP Mattson - Pharmacological reviews, 2014 - ASPET
During the past 5 decades, it has been widely promulgated that the chemicals in plants that
are good for health act as direct scavengers of free radicals. Here we review evidence that …

Unveiling the pharmacological and nanotechnological facets of daidzein: Present state-of-the-art and future perspectives

S Singh, S Grewal, N Sharma, T Behl, S Gupta… - Molecules, 2023 - mdpi.com
Herbal drugs have been attracting much scientific interest in the last few decades and
nowadays, phytoconstituents-based research is in progress to disclose their unidentified …

Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration

M Chakrabarti, A Haque, NL Banik, P Nagarkatti… - Brain research …, 2014 - Elsevier
Recent results from laboratory investigations and clinical trials indicate important roles for
estrogen receptor (ER) agonists in protecting the central nervous system (CNS) from …

Daidzein: A review of pharmacological effects

MY Sun, Y Ye, L Xiao, K Rahman, W Xia… - African journal of …, 2016 - ajol.info
Background: Daidzein is an isoflavone with extensive nutritious value and is mainly
extracted from soy plants. It is also called phytoestrogen due to its structural similarity to the …

Pueraria tuberosa: a review on its phytochemical and therapeutic potential

AK Maji, S Pandit, P Banerji… - Natural product research, 2014 - Taylor & Francis
Pueraria tuberosa (Willd.) DC is a perennial herb commonly known as 'vidarikanda',
distributed throughout south east Asia. The plant's tuber is widely used in ethanomedicine …

Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions

S Willems, L Gellrich, A Chaikuad, S Kluge, O Werz… - Cell Chemical …, 2021 - cell.com
Vitamin E exhibits pharmacological effects beyond established antioxidant activity
suggesting involvement of unidentified mechanisms. Here, we characterize endogenously …

Characterization of phenolic compounds using UPLC–HRMS and HPLC–DAD and anti-cholinesterase and anti-oxidant activities of Trifolium repens L. leaves

S Ahmad, A Zeb, M Ayaz, M Murkovic - European Food Research and …, 2020 - Springer
This study was aimed to investigate the phenolic profile of methanolic extract of Trifolium
repens L. leaves using LC–HRMS and LC–DAD and its anti--cholinesterase and anti …