Introduction Interindividual differences in drug response are a frequent clinical challenge
partly due to variation in pharmacokinetics. ATP-binding cassette (ABC) transporters are …

Pregnane X Receptor (PXR) belongs to the nuclear receptors' superfamily and mainly
functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed …

Objectives The testes are a potential viral sanctuary site for HIV-1 infection. Our study aims
to provide insight into the expression and localization of key drug transporters and metabolic …

The efficacy and safety of pharmacotherapies are determined by the complex processes
involved in the interactions between drugs with the human body, including pharmacokinetic …

NR1I2 (PXR) and NR1I3 (CAR) are nuclear receptors that are classified as xenoreceptors.
Upon activation by various xenobiotics, including marketed drugs, they regulate the …

Background Antiretroviral treatment is highly effective in enhancing HIV-positive patients'
survival and quality of life. Despite an increased tolerability in recent years, a substantial …

Background Tacrolimus is an immunosuppressor used to treat patients undergoing liver
transplantation. TDM of hematic tacrolimus by liquid chromatography became standard …

Objectives TB is currently the second cause of death among patients affected with infectious
diseases. Quantification of drug levels in plasma and in cells where Mycobacterium …

The use of HIV protease inhibitors (PIs) has extended the duration and quality of life for HIV-
positive individuals. However there is increasing concern that this antiviral therapy may …

Introduction: A remarkable inter-individual variability in the occurrence of severe side effects
represents an ongoing challenge in cancer treatment. Significant research efforts have …