The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

There is currently no accepted classification of autosomal recessive cerebellar ataxias, a
group of disorders characterized by important genetic heterogeneity and complex …

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid
scramblases and flip/floppases. However, for some intracellular membranes such as the …

Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory
chloride/bicarbonate channel in airways and intestine that is activated through ATP binding …

The TMEM16 family of membrane proteins is composed of both Ca2+-gated Cl− channels
and Ca2+-dependent phospholipid scramblases. The functional diversity of TMEM16s …

Abstract Anoctamin 3 (ANO3) belongs to a family of transmembrane proteins that form
phospholipid scramblases and ion channels. A large number of ANO3 variants were …

ABSTRACT The Ca2+‐activated Cl‒channel TMEM16A [anoctamin (ANO) 1] is homologous
to yeast Ist2 and has been shown to tether the cortical endoplasmic reticulum (ER) to the …

Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive
pulmonary disease (COPD), are characterized by mucus hypersecretion and airway …

Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …

Noxious substances, called algogens, cause pain and are used as defensive weapons by
plants and stinging insects. We identified four previously unknown instances of algogen …