This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

With its hallucinations, delusions, thought disorder, and cognitive deficits, schizophrenia
affects the most basic human processes of perception, emotion, and judgment. Evidence …

Several psychiatric disorders—such as bipolar disorder, schizophrenia and autism—are
highly heritable, yet identifying their genetic basis has been challenging, with most …

Schizophrenia is a debilitating mental illness that affects 1% of the population. Despite
intensive study, its molecular etiology remains enigmatic. Like many common diseases …

Much work has been done to identify susceptibility genes in schizophrenia and bipolar
disorder. Several well established linkages have emerged in schizophrenia. Strongly …

The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

Common mental disorders such as schizophrenia, bipolar disorder, and severe major
depression are highly heritable, but differ from single-gene (Mendelian) diseases in that they …

Abstract Disrupted-In-Schizophrenia-1 (DISC1), originally identified at the breakpoint of a
chromosomal translocation that is linked to a rare familial schizophrenia, has been …

Schizophrenia is a common and debilitating illness, characterized by chronic psychotic
symptoms and psychosocial impairment that exact considerable human and economic …

It has been conventional for psychiatric research, including the search for predisposing
genes, to proceed under the assumption that schizophrenia and bipolar disorder are …