Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …

MicroScale Thermophoresis (MST) is a powerful technique to quantify biomolecular
interactions. It is based on thermophoresis, the directed movement of molecules in a …

Coined three decades ago, the term aptamer and directed evolution have now reached their
maturity. The concept that nucleic acid could modulate the activity of target protein as ligand …

Immunotherapy has revolutionized cancer treatment, but its efficacy is severely hindered by
the lack of effective predictors. Herein, we developed a homogeneous, low‐volume, efficient …

The use of infrared laser sources for creation of localized temperature fields has opened
new possibilities for basic research and drug discovery. A recently developed technology …

Protein interactions inside the human body are expected to differ from the situation in vitro.
This is crucial when investigating protein functions or developing new drugs. In this study …

Aptamers are single‐stranded oligonucleotides that bind to targets with high affinity and
selectivity. Their use as molecular recognition elements has emerged as a viable approach …

Guanine-rich DNA sequences have the propensity to adopt four-stranded tetrahelical G-
quadruplex (G4) structures that are overrepresented in gene promoters. The structural …

The optical manipulation of tiny objects is significant to understand and to explore the
unknown in the microworld, which has found many applications in materials science and life …

The systematic evolution of ligands by exponential enrichment (SELEX) process enables the
isolation of aptamers from random oligonucleotide libraries. However, it is generally difficult …