During the last decade, genomic, transcriptomic, proteomic, metabolomic, and other omics datasets have been generated for a wide range of marine organisms, and even more are …
In this proof-of-concept work, we evaluate the performance of multiple machine-learning methods as surrogate models for use in the analysis of agent-based models (ABMs) …
X Liao, H Ma, YJ Tang - Current opinion in biotechnology, 2022 - Elsevier
Highlights•DBTL for cell factory development faces involution without breakthrough.• Machine learning can assist DBTL from genetic optimizations to fermentation controls.•The …
H Ning, R Li, T Zhou - Frontiers in Marine Science, 2022 - frontiersin.org
Microalgae are essential parts of marine ecology, and they play a key role in species balance. Microalgae also have significant economic value. However, microalgae are too …
YH Du, MY Wang, LH Yang, LL Tong, DS Guo, XJ Ji - Bioengineering, 2022 - mdpi.com
In the era of sustainable development, the use of cell factories to produce various compounds by fermentation has attracted extensive attention; however, industrial …
Predicting bioproduction titers from microbial hosts has been challenging due to complex interactions between microbial regulatory networks, stress responses, and suboptimal …
Machine learning (ML), particularly deep learning (DL), has made rapid and substantial progress in synthetic biology in recent years. Biotechnological applications of biosystems …
The availability of multi-omics data sets and genome-scale metabolic models for various organisms provide a platform for modeling and analyzing genotype-to-phenotype …
In this paper, a computational framework is proposed that merges mechanistic modeling with deep neural networks obeying the Systems Biology Markup Language (SBML) …