The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

Background: Spatial navigation is the ability to estimate one's position on the basis of
environmental and self-motion cues. Spatial memory is the cognitive substrate underlying …

Hippocampal and basal forebrain (BF) atrophy is associated with allocentric navigation
impairment in Alzheimer's disease (AD) and may lead to recruitment of compensatory …

Background Spatial navigation impairment is a promising cognitive marker of Alzheimer's
disease (AD) that can reflect the underlying pathology. Objectives We assessed spatial …

Spatial navigation (SN) impairment is present early in Alzheimer's disease (AD). We tested
whether SN performance, self-centered (egocentric) and world-centered (allocentric), was …

The current study applied a rodent-based Morris water maze (MWM) protocol to an
investigation of search performance differences between young and older adult humans. To …

A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated
with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. In Caucasians, the …

Background The ability to understand emotions is often disturbed in patients with cognitive
impairments. Right temporal lobe structures play a crucial role in emotional processing …

Purpose Identification of demographic, physical/physiological, lifestyle and genetic factors
contributing to the onset of dementia, specifically Alzheimer disease (AD), and …

Age-related spatial navigation decline is more pronounced in patients with mild cognitive
impairment (MCI) and Alzheimer's disease (AD) dementia. We used a realistic-looking …