Xanthones or 9H-xanthen-9-ones (dibenzo-γ-pirone) comprise an important class of
oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological …

This work reviews the contributions of the corresponding author (MMMP) and her research
group to Medicinal Chemistry concerning the isolation from plant and marine sources of …

Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique …

Ferroquine (FQ) is a 4-aminoquinoline antimalarial which contains a quinoline nucleus
similar to chloroquine, but a novel ferrocenic group in its side chain. Previous work has …

Abstract Changes in ε 393 (the Soret band) of aqueous ferriprotoporphyrin IX [Fe (III) PPIX]
with concentration indicate that it dimerizes, but does not form higher aggregates. Diffusion …

The antimalarial activity of 22 xanthones against chloroquino-resistant strains of
Plasmodium falciparum was evaluated. Natural caloxanthone C (1) …

A new and efficient strategy for the synthesis of substituted quinolines via electrophilic
cyclization is developed. The intramolecular cyclization of 1-azido-2-(2-propynyl) benzene 1 …

Quinoline antimalarial drugs such as chloroquine and related compounds are believed to
act by targeting ferriprotoporphyrin IX (Fe (III) PPIX) in the form of hematin (H2O/HO–Fe (III) …

It is believed that at no time in the history of the human race malaria has been absent. This
disease, which is caused by protozoa of the genus Plasmodium, in all likelihood has been …

Investigations of the marine-derived fungus Chaetomium sp. led to the isolation of the new
natural products chaetoxanthones A, B, and C (1− 3). Compounds 1 and 2 are substituted …