[HTML][HTML] Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention

NM Davis, M Sokolosky, K Stadelman, SL Abrams… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells

PKS Mahalingaiah, KP Singh - PloS one, 2014 - journals.plos.org
Accumulating evidence suggests that exposures to elevated levels of either endogenous
estrogen or environmental estrogenic chemicals are associated with breast cancer …

Exposure to Per-and Polyfluoroalkyl Substances and Breast Cancer Risk: A Systematic Review and Meta-analysis of Epidemiologic Studies

CJ Chang, JL Ish, VC Chang, M Daniel… - American Journal of …, 2024 - academic.oup.com
We synthesized the epidemiologic evidence on the associations between per-and
polyfluoroalkyl substances (PFAS) exposure and breast cancer risk. Our systematic review …

Case–control study of breast cancer and exposure to synthetic environmental chemicals among Alaska Native women

AK Holmes, KR Koller, SM Kieszak… - … journal of circumpolar …, 2014 - Taylor & Francis
Background Exposure to environmental chemicals may impair endocrine system function.
Alaska Native (AN) women may be at higher risk of exposure to these endocrine disrupting …

Organochlorine pesticide residues in human breast tissue and their relationships with clinical and pathological characteristics of breast cancer

RE Ellsworth, PJ Kostyniak, LH Chi… - Environmental …, 2018 - Wiley Online Library
Agricultural pesticides are abundant environmental contaminants worldwide, prompting
interest in studying their possible detrimental health effects. We examined organochlorine …

Childhood and adolescent pesticide exposure and breast cancer risk

NM Niehoff, HB Nichols, AJ White, CG Parks… - …, 2016 - journals.lww.com
Background: To date, epidemiologic studies have not strongly supported an association
between pesticide exposure and breast cancer. However, few previous studies had the …

Assessment of xenoestrogens in Jordanian water system: activity and identification

Y Akkam, D Omari, H Alhmoud, M Alajmi, N Akkam… - Toxics, 2023 - mdpi.com
Sex hormone disruptors (xenoestrogens) are a global concern due to their potential toxicity.
However, to date, there has been no study to investigate the presence of xenoestrogen …

Acknowledging female victims of green crimes: Environmental exposure of women to industrial pollutants

MJ Lynch - Feminist criminology, 2018 - journals.sagepub.com
Green criminology has drawn attention to the widespread forms of green victimization.
However, green criminology has neglected female victims of green crimes, and area to …

Involving the life inside: The complex interplay between reproductive axis hormones and gut microbiota

AC Organski, JS Jorgensen, TWL Cross - Current Opinion in Endocrine and …, 2021 - Elsevier
The hypothalamic-pituitary-gonadal (HPG) axis feedback loop is critical in the regulation of
the endocrine system. Dysregulation or dysfunction of the HPG axis can impact reproductive …

Pesticides and breast cancer

R Ferro, A Parvathaneni, S Patel… - Advances in Breast …, 2012 - ebooks.manu2sent.com
Along with other etiological factors like genetics, family history, age, etc. there is growing
scientific evidence that exposure to chemicals, including pesticides is associated with …