The importance of C4d in biopsies of kidney transplant recipients

RRM Corrêa, JR Machado, MV da Silva… - Journal of …, 2013 - Wiley Online Library
Antibody‐mediated rejection (AMR) is highly detrimental to the prolonged survival of
transplanted kidneys. C4d has been regarded as a footprint of AMR tissue damage, and the …

Transplant glomerulopathy: the interaction of HLA antibodies and endothelium

W Hanf, CS Bonder, PTH Coates - Journal of immunology …, 2014 - Wiley Online Library
Transplant glomerulopathy (TG) is a major cause of chronic graft dysfunction without
effective therapy. Although the histological definition of TG is well characterized, the …

[HTML][HTML] Proposed definitions of antibody-mediated rejection for use as a clinical trial endpoint in kidney transplantation

C Roufosse, JU Becker, M Rabant… - Transplant …, 2022 - frontierspartnerships.org
Antibody-mediated rejection (AMR) is caused by antibodies that recognize donor human
leukocyte antigen (HLA) or other targets. As knowledge of AMR pathophysiology has …

Rituximab, plasma exchange and immunoglobulins: an ineffective treatment for chronic active antibody-mediated rejection

GJ Piñeiro, E De Sousa-Amorim, M Solé, J Ríos… - BMC nephrology, 2018 - Springer
Background Chronic active antibody-mediated rejection (c-aABMR) is an important cause of
allograft failure and graft loss in long-term kidney transplants. Methods To determine the …

[HTML][HTML] Development and validation of a prognostic index for allograft outcome in kidney recipients with transplant glomerulopathy

P Patri, SV Seshan, M Matignon, D Desvaux, JR Lee… - Kidney international, 2016 - Elsevier
We studied 92 patients with transplant glomerulopathy to develop a prognostic index based
on the risk factors for allograft failure within five years of diagnosis (Development cohort) …

Histopathologic features of transplant glomerulopathy associated with response to therapy with intravenous immune globulin and rituximab

J Kahwaji, R Najjar, D Kancherla… - Clinical …, 2014 - Wiley Online Library
Transplant glomerulopathy (TG) is associated with poor long‐term allograft survival and is
often accompanied by microcirculation inflammation. Histopathologic scoring may inform …

[HTML][HTML] Glomerular C3 deposition is an independent risk factor for allograft failure in kidney transplant recipients with transplant glomerulopathy

SE Panzer, E Joachim, S Parajuli, W Zhong… - Kidney International …, 2019 - Elsevier
Introduction Transplant glomerulopathy (TG) becomes increasingly prevalent in kidney
transplant recipients over time, and it is strongly associated with allograft failure. To date, our …

Chronic transplant glomerulopathy: New insights into pathogenesis

A Gokhale, J Chancay, R Shapiro… - Clinical …, 2021 - Wiley Online Library
There have been recent significant advances in short‐term outcomes in renal
transplantation, however, long‐term allograft survival remains a challenge. With reported …

The relative benefits and costs of solid phase bead technology to detect preformed donor specific antihuman leukocyte antigen antibodies in determining suitability for …

HT Do Nguyen, WH Lim, JC Craig, JR Chapman… - …, 2015 - journals.lww.com
Background Screening for donor-specific anti-HLA antibodies (DSA) using bead-based
multiplex assays to determine transplant suitability is standard practice in many countries …

Transplant glomerulopathy: A brief narrative review in the light of informed literature

MT Khan, RB Hamid, N Lal - LIAQUAT MEDICAL RESEARCH …, 2024 - 121.52.154.206
Transplant glomerulopathy is characterized by a post-transplant morphologic insult. It occurs
as a consequence of chronic, periodic injury of endothelial cells triggered by chronic …