Dry eye disease (DED) is a multifactorial disorder that leads to ocular discomfort, visual
disturbance, and tear film instability. DED is accompanied by an increase in tear osmolarity …

Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle
(HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are …

Dry eye syndrome (DES), a multifactorial disorder which leads to ocular discomfort, visual
disturbance and tear film instability, has a rising prevalence and limited treatment options. In …

The specific regulatory mechanism of bladder urothelial barrier dysfunction after infection
with uropathogenic Escherichia coli (UPEC) is still unclear. The cross talk between bladder …

Inflammation is the underlying process of several diseases within the eye, specifically in the
cornea. Current treatment options for corneal inflammation or keratitis, and related …

Chronic respiratory diseases are often characterized by impaired epithelial function and
remodeling. Mast cells (MCs) are known to home into the epithelium in respiratory diseases …

Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of
asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on …

Gene silencing targeting proangiogenic factors have been shown to be a useful strategy in
the treatment of corneal neovascularization (CNV). Among interference RNA (RNAi) …

Published data indicate that the protease‐activated receptor (PAR) 2 is involved in the
pathogenesis of some cardiovascular diseases; the underlying mechanism is to be further …

Abstract Protease‐activated receptor 2 (PAR2) is a transmembrane receptor expressed by
multiple tissues, including skin, with rapidly expanding knowledge regarding its roles. In the …