Matrix metalloproteinases (MMPs), also designated matnxms, are a family of related zinc
metalloendopeptidases that function in the turnover of components of the extracellular …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

Abstract GM-CSF and M-CSF (CSF-1) induce different phenotypic changes in macrophage
lineage populations. The nature, extent, and generality of these differences were assessed …

Introduction 3. Cartilage in health and disease 4. Connective tissue degradation in arthritis
5. MMPs and cartilage degradation 6. Regulation of MMP gene expression in arthritis 7 …

We purified, cloned, and expressed aggrecanase, a protease that is thought to be
responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a …

Matrix metalloproteinases (MMPs) have a great variability that provides a complex
intervention in pathophysiological conditions. MMPs roles in pathology may be grouped into …

Chapter summary The role of matrix metalloproteinases in the degradative events invoked in
the cartilage and bone of arthritic joints has long been appreciated and attempts at the …

To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control
and diseased human articular cartilage, metabolic fragments of aggrecan were detected …

Degradation of the large cartilage proteoglycan aggrecan in arthritis involves an unidentified
enzyme aggrecanase, and at least one of the matrix metalloproteinases. Proteinase …

Arthritic diseases cause enormous burdens in terms of pain, crippling, and disability.
Osteoarthritis (OA), the most common form of arthritis, is characterized by a slow progressive …