Virulence of Helicobacter pylori outer membrane proteins: an updated review

C Xu, DM Soyfoo, Y Wu, S Xu - European Journal of Clinical Microbiology …, 2020 - Springer
Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as
gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H …

C4b-binding protein: the good, the bad and the deadly. Novel functions of an old friend

D Ermert, AM Blom - Immunology letters, 2016 - Elsevier
C4b-binding protein (C4BP) is best known as a potent soluble inhibitor of the classical and
lectin pathways of the complement system. This large 500 kDa multimeric plasma …

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

DE Fouts, MA Matthias, H Adhikarla… - PLoS neglected …, 2016 - journals.plos.org
Leptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread,
neglected and emerging zoonotic disease. While whole genome analysis of individual …

Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation

P Avirutnan, RE Hauhart, P Somnuke… - The Journal of …, 2011 - journals.aai.org
The complement system plays a pivotal protective role in the innate immune response to
many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted …

Leptospirosis: aspects of innate immunity, immunopathogenesis and immune evasion from the complement system

TR Fraga, AS Barbosa, L Isaac - Scandinavian journal of …, 2011 - Wiley Online Library
Leptospirosis is a neglected infectious disease caused by spirochetes from the genus
Leptospira. It constitutes a major public health problem in developing countries, with …

Leptospiral immunoglobulin-like proteins interact with human complement regulators factor H, FHL-1, FHR-1, and C4BP

MM Castiblanco-Valencia, TR Fraga… - Journal of Infectious …, 2012 - academic.oup.com
Leptospira, the causative agent of leptospirosis, interacts with several host molecules,
including extracellular matrix components, coagulation cascade proteins, and human …

Weil's Disease—Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota

P Petakh, V Isevych, A Kamyshnyi, V Oksenych - Biomolecules, 2022 - mdpi.com
Leptospirosis is an important zoonotic disease, causing about 60,000 deaths annually. In
this review, we have described in detail the immunopathogenesis of leptospirosis, the …

The molecular basis of leptospiral pathogenesis

GL Murray - Leptospira and leptospirosis, 2014 - Springer
The mechanisms of disease pathogenesis in leptospirosis are poorly defined. Recent
developments in the application of genetic tools in the study of Leptospira have advanced …

Complement Evasion by Pathogenic Leptospira

TR Fraga, L Isaac, AS Barbosa - Frontiers in immunology, 2016 - frontiersin.org
Leptospirosis is a neglected infectious disease caused by spirochetes from the genus
Leptospira. Pathogenic microorganisms, notably those which reach the blood circulation …

Pathogenesis of leptospirosis: cellular and molecular aspects

B Adler - Veterinary microbiology, 2014 - Elsevier
Leptospirosis is arguably the most widespread zoonosis; it is also a major cause of
economic loss in production animals worldwide. At the level of the host animal or human, the …