In the past decade, emerging synthetic biology technologies such as chemogenetics have
dramatically transformed how pharmacologists and systems biologists deconstruct the …

Elucidating the roles of neuronal cell types for physiology and behavior is essential for
understanding brain functions. Perturbation of neuron electrical activity can be used to probe …

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

▪ Abstract Immune cell–mediated destruction of pathogens may result in excessive collateral
damage to normal tissues, and the failure to control activated immune cells may cause …

A significant challenge for neuroscientists is to determine how both electrical and chemical
signals affect the activity of cells and circuits and how the nervous system subsequently …

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Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …

Inflammation must be inhibited in order to treat, eg, sepsis or autoimmune diseases or must
be selectively enhanced to improve, for example, immunotherapies of tumors or the …

Mutagenesis of the human A3 adenosine receptor (AR) suggested that certain amino acid
residues contributed differently to ligand binding and activation processes. Here we …

Adenosine receptor signaling plays important roles in normal physiology, but is also known
to modulate the development or progression of several different diseases. The design of …