Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF‐κB and the link between inflammation and cancer

JA DiDonato, F Mercurio, M Karin - Immunological reviews, 2012 - Wiley Online Library
The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

International IBD Genetics Consortium (IIBDGC)… - Nature …, 2013 - nature.com
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

Inflammation meets cancer, with NF-κB as the matchmaker

Y Ben-Neriah, M Karin - Nature immunology, 2011 - nature.com
Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …

Genetic alterations and their clinical implications in DLBCL

Y Miao, LJ Medeiros, Y Li, J Li, KH Young - Nature reviews Clinical …, 2019 - nature.com
Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …

The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance

E Zucca, F Bertoni - Blood, The Journal of the American Society …, 2016 - ashpublications.org
Extranodal marginal zone (MZ) B-cell lymphomas of the mucosa-associated lymphoid tissue
(MALT) arise from lymphoid populations that are induced by chronic inflammation in …

NF-κB in cancer: from innocent bystander to major culprit

M Karin, Y Cao, FR Greten, ZW Li - Nature reviews cancer, 2002 - nature.com
Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma

L Meriranta, A Alkodsi, A Pasanen… - Blood, The Journal …, 2022 - ashpublications.org
Inadequate molecular and clinical stratification of the patients with high-risk diffuse large B-
cell lymphoma (DLBCL) is a clinical challenge hampering the establishment of personalized …

NF-κB as a critical link between inflammation and cancer

M Karin - Cold Spring Harbor perspectives in biology, 2009 - cshperspectives.cshlp.org
NF-κB transcription factors have been suspected to be involved in cancer development
since their discovery because of their kinship with the v-Rel oncogene product. Subsequent …

Mechanisms of apoptosis

JC Reed - The American journal of pathology, 2000 - Elsevier
Programmed cell death plays critical roles in a wide variety of physiological processes
during fetal development and in adult tissues. In most cases, physiological cell death occurs …