BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

Objective To examine the potential effects of lifestyle factors on male reproductive health.
Evidence of a global decline in human sperm quality over recent decades has been …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

Climate change is affecting biodiversity, but proximate drivers remain poorly understood.
Here, we examine how experimental heatwaves impact on reproduction in an insect system …

Infertility is a widespread problem and a male contribution is involved in 20–70% of affected
couples. As a man's fertility relies on the quantity and quality of his sperm, semen analysis is …

Simple Summary Mitochondria play a crucial role in numerous cellular processes, including
energy production, apoptosis, and calcium homeostasis. In the male reproductive system …

Activation of caspase, externalization of phosphatidyl serine, change in the mitochondrial
membrane potential, and DNA fragmentation are apoptosis markers found in human …

Objective To evaluate the impact of advanced paternal age on maternal and perinatal
outcomes in the United States. Design Retrospective, population based cohort study. Setting …

Male infertility is an increasing and serious medical concern, though the mechanism
remains poorly understood. Impaired male reproductive function affects approximately half …

Oxidative stress (OS) has been implicated in a wide array of diseases such as
neurodegenerative disorders, autoimmune diseases, complex lifestyle diseases and cancer …