Ion channels are integral membrane proteins whose gating has been increasingly shown to
depend on the presence of the low-abundance membrane phospholipid …

The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans,
activated by low temperatures (> 10,< 28° C), but also a polymodal ion channel, stimulated …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Menthol is an important flavoring additive that triggers a cooling sensation. Under
physiological condition, low to moderate concentrations of menthol activate transient …

Key points We have previously shown that carotid body stimulation by lysophosphatidic acid
elicits a reflex stimulation of vagal efferent activity sufficient to cause bronchoconstriction in …

Chronic pain is a debilitating condition that affects up to 1.5 billion people worldwide and
bears a tremendous socioeconomic burden. The success of pain medicine relies on our …

In mammals, environmental cold sensing conducted by peripheral cold thermoreceptor
neurons mostly depends on TRPM8, an ion channel that has evolved to become the main …

Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful
neuropathy. The biological mechanisms that control ion channels are important for many cell …

Opioids are powerful analgesic drugs that are used clinically to treat pain. However, chronic
opioid use causes compensatory neuroadaptations that result in greater pain sensitivity …

Transient receptor potential melastatin 8 (TRPM8) channels play a central role in the
detection of environmental cold temperatures in the somatosensory system. TRPM8 is found …