A Saudi Arabian public health perspective of tuberculosis

AA Saati, M Khurram, H Faidah, A Haseeb… - International Journal of …, 2021 - mdpi.com
Tuberculosis is a global health challenge due to its spreading potential. The Kingdom of
Saudi Arabia (KSA) faces a challenge in the spread of tuberculosis from migrant workers …

[HTML][HTML] Stratifying sepsis in Uganda using rapid pathogen diagnostics and clinical data: a prospective cohort study

MJ Cummings, B Bakamutumaho, N Owor… - The American Journal …, 2021 - ncbi.nlm.nih.gov
The global burden of sepsis is concentrated in sub-Saharan Africa, where extensive
pathogen diversity and limited laboratory capacity challenge targeted antimicrobial …

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and critical illness

PS Rao, CC Moore, AA Mbonde, E Nuwagira… - Antibiotics, 2021 - mdpi.com
Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate
for people living with human immunodeficiency virus (HIV). Critical illness can lead to …

Population study on diagnosis, treatment and outcomes of critically ill patients with tuberculosis (2008–2018)

C So, L Ling, WT Wong, JZ Zhang, CM Ho, PY Ng… - Thorax, 2023 - thorax.bmj.com
Background Tuberculosis (TB) is a preventable and curable disease, but mortality remains
high among those who develop sepsis and critical illness from TB. Methods This was a …

Towards Improved Management of Tuberculous Bloodstream Infections: Pharmacokinetic Considerations with Suggestions for Better Treatment Outcomes

CO Odongo, L Nakiyingi, CG Nkeramihigo, D Seifu… - Antibiotics, 2022 - mdpi.com
Mycobacterium tuberculosis is the leading cause of sepsis among HIV-infected adults, yet
effective treatment remains a challenge. Efficacy of antituberculous drugs is optimized by …

Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial

B Said, E Nuwagira, A Liyoyo, R Arinaitwe, C Gitige… - BMJ open, 2022 - bmjopen.bmj.com
Introduction Sub-Saharan Africa shoulders the highest burden of global sepsis and
associated mortality. In high HIV and tuberculosis (TB) prevalent settings such as sub …

Performance of the Universal Vital Assessment (UVA) mortality risk score in hospitalized adults with infection in Rwanda: A retrospective external validation study

R Hazard, D Bagenda, AJ Patterson, JT Hoffman… - Plos one, 2022 - journals.plos.org
Background We previously derived a Universal Vital Assessment (UVA) score to better risk-
stratify hospitalized patients in sub-Saharan Africa, including those with infection. Here, we …

[HTML][HTML] Protocol: Early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan Africa: a protocol of a randomised clinical trial

B Said, E Nuwagira, A Liyoyo, R Arinaitwe, C Gitige… - BMJ Open, 2022 - ncbi.nlm.nih.gov
ABSTRACT Introduction Sub-Saharan Africa shoulders the highest burden of global sepsis
and associated mortality. In high HIV and tuberculosis (TB) prevalent settings such as sub …

[PDF][PDF] Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness. Antibiotics 2021, 10, 739

PS Rao, CC Moore, AA Mbonde, E Nuwagira… - 2021 - academia.edu
Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate
for people living with human immunodeficiency virus (HIV). Critical illness can lead to …

Causes and consequences of adult sepsis in Blantyre, Malawi

J Lewis - 2019 - archive.lstmed.ac.uk
Sepsis, defined as a life-threatening organ dysfunction triggered by infection, carries a high
mortality. Recent improvements in outcome high-income settings have been driven by …