The importance of 3D fibre architecture in cancer and implications for biomaterial model design

JC Ashworth, TR Cox - Nature Reviews Cancer, 2024 - nature.com
The need for improved prediction of clinical response is driving the development of cancer
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …

[HTML][HTML] MSCs-derived decellularised matrix: cellular responses and regenerative dentistry

S Phothichailert, S Samoun, BP Fournier, J Isaac… - International Dental …, 2024 - Elsevier
The decellularised extracellular matrix (dECM) of in vitro cell culture is a naturally derived
biomaterial formed by the removal of cellular components. The compositions of molecules in …

Evaluation of proton-induced DNA damage in 3D-engineered glioblastoma microenvironments

Q Akolawala, M Rovituso, HH Versteeg… - … applied materials & …, 2022 - ACS Publications
Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis.
For this reason, besides clinical and preclinical studies, novel in vitro models for the …

Micro‐Vessels‐Like 3D Scaffolds for Studying the Proton Radiobiology of Glioblastoma‐Endothelial Cells Co‐Culture Models

Q Akolawala, F Keuning, M Rovituso… - Advanced …, 2024 - Wiley Online Library
Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis.
While X‐ray radiotherapy and chemotherapy remain the current standard, proton beam …

Corneal fibrosis: From in vitro models to current and upcoming drug and gene medicines

LT Cubillo, M Gurdal, DI Zeugolis - Advanced Drug Delivery Reviews, 2024 - Elsevier
Fibrotic diseases are characterised by myofibroblast differentiation, uncontrolled
pathological extracellular matrix accumulation, tissue contraction, scar formation and …

[HTML][HTML] Macromolecular crowding in the development of a three-dimensional organotypic human breast cancer model

N Shologu, M Gurdal, E Szegezdi, U FitzGerald… - Biomaterials, 2022 - Elsevier
Although cell-derived matrices are at the forefront of scientific research and technological
innovation for the development of in vitro tumour models, their two-dimensional structure …

Combining Cryogel Architecture and Macromolecular Crowding‐Enhanced Extracellular Matrix Cues to Mimic the Bone Marrow Niche

L Martínez‐Vidal, V Magno, PB Welzel… - Macromolecular …, 2023 - Wiley Online Library
Transplantation of hematopoietic stem cells (HSCs)—rare cells that can self‐renew and
differentiate into cells of all hematopoietic lineages—is an important treatment option for …

[HTML][HTML] Engineering cell-derived extracellular matrix for peripheral nerve regeneration

Y Xu, X Liu, MA Ahmad, Q Ao, Y Yu, D Shao, T Yu - Materials Today Bio, 2024 - Elsevier
Extracellular matrices (ECMs) play a key role in nerve repair and are recognized as the
natural source of biomaterials. In parallel to extensively studied tissue-derived ECMs (ts …

Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells (iPSCs)

GR Mazarura, TE Hébert - Molecular Pharmacology, 2024 - Elsevier
Fibrosis is implicated in nearly all forms of cardiomyopathy and significantly influences
disease severity and outcomes. The primary cell responsible for fibrosis is the cardiac …

Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells

GR Mazarura, TE Hébert - Molecular Pharmacology, 2025 - molpharm.aspetjournals.org
Fibrosis is implicated in nearly all forms of cardiomyopathy and significantly influences
disease severity and outcomes. The primary cell responsible for fibrosis is the cardiac …