RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …

Cancer has long been viewed as a disease of normal development gone awry. Cancer stem-
like cells (CSCs), also termed as tumor-initiating cells (TICs), are increasingly recognized as …

Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …

The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …

Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory
mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) …

Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Breast cancer is the most common cancer in women worldwide. MicroRNAs (miRNAs) are
non-coding RNAs that are involved in the post-transcriptional regulation of gene expression …

Accumulating evidence suggests that aerobic glycolysis is important for colorectal cancer
(CRC) development. However, the underlying mechanisms have yet to be elucidated. B7 …