The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug‐
seeking and drug‐taking behaviours. Given the significant detrimental effects of this disease …

Over the past several years, drug addiction has increasingly been accepted to be a disease
of the brain as opposed to simply being due to a lack of willpower or personality flaw …

Lifetime relapse rates remain a major obstacle in addressing the current opioid crisis.
Relapse to opioid use can be modeled in rodent studies where drug self-administration is …

Learned associations between drugs and environment play an important role in addiction
and are thought to be encoded within specific patterns of sparsely distributed neurons called …

Ethanol and opiate self-administration are sensitive to manipulations of cannabinoid CB1
receptor function and, from this, a role for the endogenous cannabinoid system in the …

Reinstatement of extinguished drug-seeking has been utilized in the study of the neural
substrates of relapse to drugs of abuse, particularly cocaine. However, limited studies have …

Previous studies have shown reduced hypothalamo-pituitary-adrenal responses to both
acute and chronic restraint stressors in rats allowed to ingest highly palatable foods (32 …

Development of pharmacotherapy to reduce relapse rates is one of the biggest challenges
in drug addiction research. The enduring nature of relapse suggests that it is maintained by …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …