Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac
and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 …

Rho GTPase activation, which is mediated by guanine nucleotide exchange factors (GEFs),
is tightly regulated in time and space. Although Rho GTPases have a significant role in many …

The Rho family of small GTPases are important regulators of multiple cellular activities and,
most notably, reorganization of the actin cytoskeleton. Dbl-homology (DH)-domain …

Background Tumor cells can move in a three-dimensional (3D) environment in either
mesenchymal-type or amoeboid modes. In mesenchymal-type movement, cells have an …

Dysregulation of gene expression in islets from patients with type 2 diabetes (T2D) might be
causally involved in the development of hyperglycemia, or it could develop as a …

Cell migration is a highly regulated multistep process that requires the coordinated
regulation of cell adhesion, protrusion, and contraction. These processes require numerous …

The hepatitis B virus (HBV) infects many people worldwide. As HBV infection frequently
leads to liver fibrosis and carcinogenesis, developing anti-HBV therapeutic drugs is urgent …

The discovery of the molecular basis of this disease is expected to facilitate diagnosis and
definitive treatment with hematopoietic cell transplantation. Further research is needed to …

Chemokine signals activate leukocyte integrins and actin remodeling machineries critical for
leukocyte adhesion and motility across vascular barriers. The arrest of leukocytes at target …

Abstract During angiogenesis, Rho-GTPases influence endothelial cell migration and cell–
cell adhesion; however it is not known whether they control formation of vessel lumens …