DNA in nanochannels: theory and applications
Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …
The molecular functions of MeCP2 in Rett syndrome pathology
MeCP2 protein, encoded by the MECP2 gene, binds to DNA and affects transcription.
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …
Gradient nanoconfinement facilitates binding of transcriptional factor NF-κB to histone-and protamine-DNA complexes
Mechanically induced chromosome reorganization plays important roles in transcriptional
regulation. However, the interplay between chromosome reorganization and transcription …
regulation. However, the interplay between chromosome reorganization and transcription …
Density control over MBD2 receptor-coated surfaces provides superselective binding of hypermethylated DNA
RW Kolkman, S Michel-Souzy… - … applied materials & …, 2022 - ACS Publications
Using the biomarker hypermethylated DNA (hmDNA) for cancer detection requires a
pretreatment to isolate or concentrate hmDNA from nonmethylated DNA. Affinity …
pretreatment to isolate or concentrate hmDNA from nonmethylated DNA. Affinity …
RettDb: the Rett syndrome omics database to navigate the Rett syndrome genomic landscape
Rett syndrome (RTT) is a neurodevelopmental disorder occurring almost exclusively in
females and leading to a variety of impairments and disabilities from mild to severe. In> 95 …
females and leading to a variety of impairments and disabilities from mild to severe. In> 95 …
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures
EM Irvin, H Wang - DNA repair, 2023 - Elsevier
DNA repair pathways are tightly regulated processes that recognize specific hallmarks of
DNA damage and coordinate lesion repair through discrete mechanisms, all within the …
DNA damage and coordinate lesion repair through discrete mechanisms, all within the …
Selective enrichment of hypermethylated DNA by a multivalent binding platform
RW Kolkman, LI Segerink… - Advanced Materials …, 2022 - Wiley Online Library
The preselection of hypermethylated DNA (hmDNA) from liquid biopsy samples is key to
enable early‐stage cancer diagnostics. Due to limited selectivity of the existing preselection …
enable early‐stage cancer diagnostics. Due to limited selectivity of the existing preselection …
A prelude to the proximity interaction mapping of CXXC5
CXXC5 is a member of the zinc-finger CXXC family proteins that interact with unmodified
CpG dinucleotides through a conserved ZF-CXXC domain. CXXC5 is involved in the …
CpG dinucleotides through a conserved ZF-CXXC domain. CXXC5 is involved in the …
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart
Background Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients.
Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and …
Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and …
Computational discovery of novel inhibitory candidates targeting versatile transcriptional repressor MBD2
ZO Çalışkaner - Journal of Molecular Modeling, 2022 - Springer
Genome methylation is a key epigenetic mechanism in various biological events such as
development, cellular differentiation, cancer progression, aging, and iPSC reprogramming …
development, cellular differentiation, cancer progression, aging, and iPSC reprogramming …