In situ forming implants (ISI) based on phase separation by solvent exchange represent an
attractive alternative to conventional preformed implants and microparticles for parenteral …

In situ forming implants, defined as liquid formulations that generate solid or semisolid
depots following administration, have shown a range of advantages in drug delivery. This …

Here we report an ultra-long-acting tunable, biodegradable, and removable polymer-based
delivery system that offers sustained drug delivery for up to one year for HIV treatment or …

Poly (lactic-co-glycolic acid)(PLGA) is one of the preferred polymeric inactive ingredients for
long-acting parenteral drug products that are constituted of complex formulations. Despite …

Burst release of encapsulated drug with release of a significant fraction of payload into
release medium within a short period, both in vitro and in vivo, remains a challenge for …

In situ forming (ISF) drug delivery implants have gained tremendous levels of interest over
the last few decades. This is due to their wide range of biomedical applications such as in …

Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase
adherence and maximize public health benefit. We report on an injectable, biodegradable …

In situ forming drug delivery implants offer an attractive alternative to pre-formed implant
devices for local drug delivery due to their ability to deliver fragile drugs, simple …

Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis (Mtb)
and is a major cause of morbidity and mortality. Successful treatment requires strict …

In-situ forming implants (ISFIs) represent a simple, tunable, and biodegradable polymer-
based platform for long-acting drug delivery. However, drugs with different physicochemical …