The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …

Synapses are formed by interneuronal connections that permit a neuronal cell to pass an
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …

To decipher dynamic brain information processing, current genetically encoded calcium
indicators (GECIs) are limited in single action potential (AP) detection speed, combinatorial …

Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

CREB and its close relatives are now widely accepted as prototypical stimulus-inducible
transcription factors. In many cell types, these factors function as effector molecules that …

Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors
have opposite effects on CREB (cAMP response element binding protein) function, gene …

▪ Abstract Extracellular stimuli elicit changes in gene expression in target cells by activating
intracellular protein kinase cascades that phosphorylate transcription factors within the …