Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
Complex spherical fuzzy Aczel Alsina aggregation operators and their application in assessment of electric cars
The multi-criteria decision-making (MCDM) tool is a robust decision-making technique
utilized in several fields like networking, risk management, digital analysis, cybercrime …
utilized in several fields like networking, risk management, digital analysis, cybercrime …
In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications
A Pałasz, D Cież - European journal of medicinal chemistry, 2015 - Elsevier
This review article is an effort to summarize recent developments in researches providing
uracil derivatives with promising biological potential. This article also aims to discuss …
uracil derivatives with promising biological potential. This article also aims to discuss …
Advances in the development of hybrid anticancer drugs
Introduction: Hybrid anticancer drugs are of great therapeutic interests as they can
potentially overcome most of the pharmacokinetic drawbacks encountered when using …
potentially overcome most of the pharmacokinetic drawbacks encountered when using …
Recent advances in isatin hybrids as potential anticancer agents
Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for therapeutic coumarin hybrids
Hybrid molecules, furnished by combining two or more pharmacophores is an emerging
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
concept in the field of medicinal chemistry and drug discovery that has attracted substantial …
Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies
In an attempt to develop potent anti-tubulin agents against most dreadful disease cancer, a
library of 28 novel triazole tethered isatin-coumarin hybrids were synthesized by click …
library of 28 novel triazole tethered isatin-coumarin hybrids were synthesized by click …
A mini review on pharmacological significance of isatin-1, 2, 3-triazole hybrids
Molecular hybridization is one of the recent stratagems in medicinal chemistry to synthesize
a novel hybrid molecule having better affinity and efficacy by combining two or more …
a novel hybrid molecule having better affinity and efficacy by combining two or more …
Azide-alkyne cycloaddition en route to 1H-1, 2, 3-triazole-tethered 7-chloroquinoline-isatin chimeras: Synthesis and antimalarial evaluation
We describe the synthesis and antimalarial activities of 1H-1, 2, 3-triazole tethered 7-
chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 …
chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 …