International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders

J Hillengass, S Usmani, SV Rajkumar… - The lancet …, 2019 - thelancet.com
Recent advances in the treatment of multiple myeloma have increased the need for accurate
diagnosis of the disease. The detection of bone and bone marrow lesions is crucial in the …

International harmonization in performing and reporting minimal residual disease assessment in multiple myeloma trials

LJ Costa, BA Derman, S Bal, S Sidana, S Chhabra… - Leukemia, 2021 - nature.com
Minimal residual disease (MRD) assessment is incorporated in an increasing number of
multiple myeloma (MM) clinical trials as a correlative analysis, an endpoint or even as a …

Daratumumab, carfilzomib, lenalidomide, and dexamethasone with minimal residual disease response-adapted therapy in newly diagnosed multiple myeloma

LJ Costa, S Chhabra, E Medvedova… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE The MASTER trial combined daratumumab, carfilzomib, lenalidomide, and
dexamethasone (Dara-KRd) in newly diagnosed multiple myeloma (NDMM), using minimal …

A large meta-analysis establishes the role of MRD negativity in long-term survival outcomes in patients with multiple myeloma

NC Munshi, H Avet-Loiseau, KC Anderson… - Blood …, 2020 - ashpublications.org
The prognostic value of minimal residual disease (MRD) for progression-free survival (PFS)
and overall survival (OS) was evaluated in a large cohort of patients with multiple myeloma …

Measurable residual disease by next-generation flow cytometry in multiple myeloma

B Paiva, N Puig, MT Cedena, L Rosiñol… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Assessing measurable residual disease (MRD) has become standard with many
tumors, but the clinical meaning of MRD in multiple myeloma (MM) remains uncertain …

Standardization of 18F-FDG–PET/CT According to Deauville Criteria for Metabolic Complete Response Definition in Newly Diagnosed Multiple Myeloma

E Zamagni, C Nanni, L Dozza, T Carlier… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed
tomography (CT) is currently the standard technique to define minimal residual disease …

Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard-and high-risk myeloma

I Goicoechea, N Puig, MT Cedena… - Blood, The Journal …, 2021 - ashpublications.org
Patients with multiple myeloma (MM) carrying standard-or high-risk cytogenetic
abnormalities (CAs) achieve similar complete response (CR) rates, but the later have inferior …

NCCN guidelines insights: Multiple myeloma, version 1.2020: Featured updates to the NCCN guidelines

SK Kumar, NS Callander, J Hillengass… - Journal of the National …, 2019 - jnccn.org
The NCCN Guidelines for Multiple Myeloma provide recommendations for diagnosis,
workup, treatment, follow-up, and supportive care for patients with monoclonal gammopathy …

[HTML][HTML] The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states

L Rasche, C Schinke, F Maura, MA Bauer… - Nature …, 2022 - nature.com
Abstract Deciphering Multiple Myeloma evolution in the whole bone marrow is key to inform
curative strategies. Here, we perform spatial-longitudinal whole-exome sequencing …

Minimal residual disease in myeloma: application for clinical care and new drug registration

KC Anderson, D Auclair, SJ Adam, A Agarwal… - Clinical Cancer …, 2021 - AACR
The development of novel agents has transformed the treatment paradigm for multiple
myeloma, with minimal residual disease (MRD) negativity now achievable across the entire …