[HTML][HTML] eQTL studies: from bulk tissues to single cells

J Zhang, H Zhao - Journal of Genetics and Genomics, 2023 - Elsevier
An expression quantitative trait locus (eQTL) is a chromosomal region where genetic
variants are associated with the expression levels of specific genes that can be both nearby …

Statistical Inference of Cell-type Proportions Estimated from Bulk Expression Data

B Cai, EJ Zhang, H Li, C Su, H Zhao - Journal of the American …, 2024 - Taylor & Francis
There is a growing interest in cell-type-specific analysis from bulk samples with a mixture of
different cell types. A critical first step in such analyses is the accurate estimation of cell-type …

[HTML][HTML] DeepDecon accurately estimates cancer cell fractions in bulk RNA-seq data

J Huang, Y Du, A Stucky, KR Kelly, JF Zhong, F Sun - Patterns, 2024 - cell.com
Understanding the cellular composition of a disease-related tissue is important in disease
diagnosis, prognosis, and downstream treatment. Recent advances in single-cell RNA …