Activating receptor tyrosine kinase RET (rarranged during transfection) gene alterations
have been identified as oncogenic in multiple malignancies. RET gene rearrangements …

The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

In multicellular organisms, communication between individual cells is essential for the
regulation and coordination of complex cellular processes such as growth, differentiation …

Background An age-related progression from C-cell hyperplasia to medullary thyroid
carcinoma is associated with various germ-line mutations in the rearranged during …

Neuroblastoma (NB) is a frequent pediatric tumor for which recurrent somatic
rearrangements are known. Germline mutations of predisposing gene (s) are suspected on …

Glial cell line-derived neurotrophic factor (GDNF) and related molecules, neurturin, artemin
and persephin, signal through a unique multicomponent receptor system consisting of RET …

The RET gene encodes a receptor tyrosine kinase that is expressed in neural crest-derived
cell lineages. The RET receptor plays a crucial role in regulating cell proliferation, migration …

The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived
neurotrophic factor family of ligands. Loss-of-function mutations in RET are implicated in …

The activation of the RET proto-oncogene contributes to the development of human cancers
in two different ways. Somatic rearrangements of RET with a variety of activating genes …

Receptor tyrosine kinases (RTKs) are the primary mediators of the signaling network that
transmit extracellular signals into the cell. Gene amplification and/or overexpression of RTK …