An update on treatment options for pancreatic adenocarcinoma

A Lambert, L Schwarz, I Borbath… - … in medical oncology, 2019 - journals.sagepub.com
Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence,
late diagnosis, and limited treatment options, it is expected to be the second leading cause …

FOLFIRINOX or gemcitabine-based chemotherapy for borderline resectable and locally advanced pancreatic cancer: a multi-institutional, patient-level, meta-analysis …

D Eshmuminov, B Aminjonov, RF Palm… - Annals of surgical …, 2023 - Springer
Background Pancreatic cancer often presents as locally advanced (LAPC) or borderline
resectable (BRPC). Neoadjuvant systemic therapy is recommended as initial treatment. It is …

Efficacy and safety of neoadjuvant gemcitabine plus nab-paclitaxel in borderline resectable and locally advanced pancreatic cancer—a systematic review and meta …

M Damm, L Efremov, B Birnbach, G Terrero, J Kleeff… - Cancers, 2021 - mdpi.com
Simple Summary Due to the availability of effective combination chemotherapies such as
gemcitabine/nab-paclitaxel (GNP) or FOLFIRINOX, neoadjuvant treatment of borderline …

Optimizing first-line chemotherapy in metastatic pancreatic cancer: efficacy of FOLFIRINOX versus nab-paclitaxel plus gemcitabine

F Di Costanzo, F Di Costanzo, L Antonuzzo, E Mazza… - Cancers, 2023 - mdpi.com
Simple Summary Metastatic PC often represents a complex decision-making moment for
oncologists, particularly due to the general conditions of the patients, age, and the potential …

The role of FOLFIRINOX in metastatic pancreatic cancer: A meta-analysis

B Zhang, F Zhou, J Hong, DM Ng, T Yang… - World Journal of …, 2021 - Springer
Background The prognosis of pancreatic cancer (PC) is extremely poor, and most patients
with metastatic PC still receive palliative care. Here, we report the efficacy and safety of …

Immunomodulatory effect after irreversible electroporation in patients with locally advanced pancreatic cancer

C He, J Wang, S Sun, Y Zhang, S Li - Journal of oncology, 2019 - Wiley Online Library
Purpose. Irreversible electroporation (IRE) has been demonstrated to be a safe and effective
method for locally advanced pancreatic cancer (LAPC). The aim of this study was to …

Modified FOLFIRINOX in pancreatic cancer patients age 75 or older

JD Mizrahi, JE Rogers, KR Hess, RA Wolff… - Pancreatology, 2020 - Elsevier
Abstract Background Although FOLFIRINOX (5-Fluorouracil+ leucovorin+ irinotecan+
oxaliplatin) is now the standard of care for patients (pts) with metastatic pancreatic cancer …

Irreversible electroporation after induction chemotherapy versus chemotherapy alone for patients with locally advanced pancreatic cancer: A propensity score …

C He, J Wang, Y Zhang, X Lin, S Li - Pancreatology, 2020 - Elsevier
Background Locally advanced pancreatic cancer (LAPC) is a devastating disease and
irreversible electroporation (IRE) is a non-thermal ablation method that is especially suitable …

[HTML][HTML] Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities

M Manrai, T Tilak, S Dawra, S Srivastava… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Pancreatic carcinoma (PC) is one of the leading causes of cancer-related deaths worldwide.
Despite early detection and advances in therapeutics, the prognosis remains dismal. The …

Combining CD40 agonist mitazalimab with mFOLFIRINOX in previously untreated metastatic pancreatic ductal adenocarcinoma (OPTIMIZE-1): a single-arm …

JL Van Laethem, I Borbath, H Prenen… - The Lancet …, 2024 - thelancet.com
Background Current systemic therapies for metastatic pancreatic ductal adenocarcinoma
are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed …