Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among
elderly individuals and is recognized as a major vascular contributor to dementia, cognitive …

Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured
not only in cerebrospinal fluid but also in serum, which allows for repeated assessments …

Cerebrovascular disease typically manifests with stroke, cognitive impairment, or both.
Vascular cognitive impairment refers to all forms of cognitive disorder associated with …

White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

Despite the global impact and advances in understanding the pathophysiology of
cerebrovascular diseases, the term “stroke” is not consistently defined in clinical practice, in …

Little is still known about the neuroanatomical substrates related to changes in specific
cognitive abilities in the course of healthy aging, and the existing evidence is predominantly …

White matter hyperintensities are associated with increased risk of dementia and cognitive
decline. The current study investigates the relationship between white matter …

Objectives To review the evidence for an association of white matter hyperintensities with
risk of stroke, cognitive decline, dementia, and death. Design Systematic review and meta …

Structural imaging based on magnetic resonance is an integral part of the clinical
assessment of patients with suspected Alzheimer dementia. Prospective data on the natural …