Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

P Chen, M Wu, Y He, B Jiang, ML He - Signal Transduction and …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …

COVID‐19 metabolism: Mechanisms and therapeutic targets

T Wang, Y Cao, H Zhang, Z Wang, CH Man… - MedComm, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral
signaling, immune response, and cell metabolism in human body. Viral genome and …

Precision management of post‐COVID pain: An evidence and clinical‐based approach

C Fernández‐de‐las‐Peñas, J Nijs… - … Journal of Pain, 2023 - Wiley Online Library
Background Pain after a SARS‐CoV‐2 acute infection (post‐COVID pain) is becoming a
new healthcare emergency but remains underestimated and most likely undertreated due to …

Psychological and cognitive effects of long COVID: a narrative review focusing on the assessment and rehabilitative approach

R De Luca, M Bonanno, RS Calabrò - Journal of clinical medicine, 2022 - mdpi.com
Long COVID is a clinical syndrome characterized by profound fatigue, neurocognitive
difficulties, muscle pain, weakness, and depression, lasting beyond the 3–12 weeks …

Mapping the Lipid Signatures in COVID-19 Infection: Diagnostic and Therapeutic Solutions

A Dasgupta, S Gangai, R Narayan… - Journal of Medicinal …, 2023 - ACS Publications
The COVID-19 pandemic ignited research centered around the identification of robust
biomarkers and therapeutic targets. SARS-CoV-2, the virus responsible, hijacks the …

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

AS Naidu, CK Wang, P Rao, F Mancini… - npj Science of …, 2024 - nature.com
Abstract SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic
capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic …

Blood gene expression predicts intensive care unit admission in hospitalised patients with COVID-19

R Penrice-Randal, X Dong, AG Shapanis… - Frontiers in …, 2022 - frontiersin.org
Background The COVID-19 pandemic has created pressure on healthcare systems
worldwide. Tools that can stratify individuals according to prognosis could allow for more …

Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine

I Piano, A Votta, P Colucci, F Corsi, S Vitolo, C Cerri… - Scientific Reports, 2023 - nature.com
Microglia chronic activation is a hallmark of several neurodegenerative diseases, including
the retinal ones, possibly contributing to their etiopathogenesis. However, some microglia …

The use of palmitoylethanolamide in the treatment of long COVID: a real-life retrospective cohort study

L Raciti, R De Luca, G Raciti, FA Arcadi, RS Calabrò - Medical Sciences, 2022 - mdpi.com
COVID-19 can cause symptoms that last weeks or months after the infection has gone, with
a significant impairment of quality of life. Palmitoylethanolamide (PEA) is a naturally …

Research advances on the role of lipids in the life cycle of human coronaviruses

C Ding, Y Chen, G Miao, Z Qi - Microorganisms, 2023 - mdpi.com
Coronaviruses (CoVs) are emerging pathogens with a significant potential to cause life-
threatening harm to human health. Since the beginning of the 21st century, three highly …