Ecology Letters (2011) 14: 1052–1061 Abstract The scope and magnitude of anthropogenic
noise pollution are often much greater than those of natural noise and are predicted to have …

Modern research has provided new in-sights into the biological mechanisms of noise-
induced hearing loss, and with these new insights comes hope for possible prevention or …

Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia
neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD+) …

Hearing loss caused by exposure to recreational and occupational noise remains a
worldwide disabling condition and dysregulation of redox homeostasis is the hallmark of …

Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a
result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological …

Programmed cell death (PCD)—apoptosis, autophagy and programmed necrosis—is any
pathological form of cell death mediated by intracellular processes. Ototoxic drugs, ageing …

Peroxisomes are involved in multiple metabolic processes, including fatty acid oxidation,
ether lipid synthesis, and reactive oxygen species (ROS) metabolism. Recent studies …

Reactive oxygen species (ROS) play a major role in drug-, noise-, and age-dependent
hearing loss, but the source of ROS in the inner ear remains largely unknown. Herein, we …

The base of the cochlea is more vulnerable to trauma than the apex as seen in the pattern of
hair cell damage by cisplatin or aminoglycosides. The differential vulnerability is maintained …

Recent research has shown the essential role of reduced blood flow and free radical
formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and …