A molecular understanding of high-density lipoprotein (HDL) will allow a more complete
grasp of its interactions with key plasma remodelling factors and with cell-surface proteins …

Three‐dimensional (3D) structural analysis is essential to understand the relationship
between the structure and function of an object. Many analytical techniques, such as X‐ray …

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no
specific and effective drugs for treating this disease have been reported until today …

Metabolic coordination between neurons and astrocytes is critical for the health of the brain.
However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural …

The molecular heterogeneity of extracellular vesicles (EVs) and the co‐isolation of
physically similar particles, such as lipoproteins (LPs), confounds and limits the sensitivity of …

Commonly used methods for determining protein structure, including X-ray crystallography
and single-particle reconstruction, often provide a single and unique three-dimensional (3D) …

Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl
ester mass from atheroprotective high-density lipoproteins to atherogenic low-density …

Rationale: CSL112, human apolipoprotein AI (apoA-I) reconstituted with
phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein …

A promising tool in membrane research is the use of the styrene–maleic acid (SMA)
copolymer to solubilize membranes in the form of nanodiscs. Since membranes are …

Amphipathic copolymers such as poly (styrene-maleic acid)(SMA) are promising tools for the
facile extraction of membrane proteins (MPs) into native nanodiscs. Here, we designed and …