Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

The predicted protein encoded by the APJ gene discovered in 1993 was originally classified
as a class AG protein-coupled orphan receptor but was subsequently paired with a novel …

Severe obesity represents a major risk factor for the development of type 2 diabetes mellitus
(T2DM). Due to the strong association of obesity and diabetes, the term “diabesity” was …

The prevalence of maternal obesity during pregnancy is associated with the risk of
gestational diabetes, preeclampsia, and cardiomyopathy. Environmental factors such as …

Lifestyle changes have made metabolic disorders as one of the major threats to life. Growing
evidence demonstrates that obesity and diabetes disrupt the reproductive system by …

Previously, we demonstrated the expression of apelin and G-protein-coupled receptor APJ
in human placenta cell lines as well as its direct action on placenta cell proliferation and …

Background: Diabetic retinopathy is one of the important complications of diabetes. In major
cases, diabetic retinopathy is unnoticed until the irreversible damage to eye occurs and …

Apelin (APLN), as a ligand for APJ (an orphan G-protein-coupled receptor), is an adipokine
with pleiotropic effects in many physiological processes of the body. It has an important role …

Adipokines are a family of hormones and cytokines with both pro‐and anti‐inflammatory
effects released into the circulation to exert their hormonal effects. Adipokines are closely …

Purpose Apelin treatment has been shown to improve insulin sensitivity in insulin resistant
mice by acting in skeletal muscles. However, the effects of systemic apelin on the hepatic …