[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Nrf2/Keap1/ARE signaling: Towards specific regulation
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …
defense against oxidative stress, the hallmark of numerous diseases such as …
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
Sickle cell disease (SCD) is caused by a mutation in the β-globin gene HBB. We used a
custom adenine base editor (ABE8e-NRCH), to convert the SCD allele (HBB S) into …
custom adenine base editor (ABE8e-NRCH), to convert the SCD allele (HBB S) into …
Chronic and acute toxicities of aflatoxins: Mechanisms of action
N Benkerroum - International journal of environmental research and …, 2020 - mdpi.com
There are presently more than 18 known aflatoxins most of which have been insufficiently
studied for their incidence, health-risk, and mechanisms of toxicity to allow effective …
studied for their incidence, health-risk, and mechanisms of toxicity to allow effective …
Circadian regulator BMAL1:: CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle
Hepatocellular carcinoma (HCC) remains a global health challenge whose incidence is
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …
Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers
M Su, Y Xiao, J Ma, Y Tang, B Tian, Y Zhang, X Li… - Molecular cancer, 2019 - Springer
Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability.
CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location-and …
CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location-and …
Algorithmic assessment of cellular senescence in experimental and clinical specimens
The development of genetic tools allowed for the validation of the pro-aging and pro-disease
functions of senescent cells in vivo. These discoveries prompted the development of …
functions of senescent cells in vivo. These discoveries prompted the development of …
Anticancer potential of furanocoumarins: mechanistic and therapeutic aspects
Cancer is one of the most extreme medical conditions in both developing and developed
countries around the world, causing millions of deaths each year. Chemotherapy and/or …
countries around the world, causing millions of deaths each year. Chemotherapy and/or …
Epigenetic regulation of cellular senescence
J Crouch, M Shvedova, RJRS Thanapaul… - Cells, 2022 - mdpi.com
Senescence is a complex cellular stress response that abolishes proliferative capacity and
generates a unique secretory pattern that is implicated in organismal aging and age-related …
generates a unique secretory pattern that is implicated in organismal aging and age-related …
miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways
G Bi, J Liang, M Zhao, H Zhang, X Jin, T Lu… - … Therapy-Nucleic Acids, 2022 - cell.com
Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide.
Combination chemotherapy with cisplatin (CDDP) plus pemetrexed (PEM) remains the …
Combination chemotherapy with cisplatin (CDDP) plus pemetrexed (PEM) remains the …