Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …

Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

Nuclear factor erythroid 2‐related factor 2 (Nrf2) is considered as the sensor of oxidative
stress, and the main aim of this signaling pathway is to maintain physiological condition by …

Anoikis resistance is an essential prerequisite for tumor metastasis, but the underlying
molecular mechanisms remain unknown. Herein, we report that the oncoprotein hepatitis B …

Since the beginning of the 21st century, studies have focused on developing drugs from
naturally occurring compounds. Berberine (Brb) as a plant‐derived compound is of interest …

Oxidative stress is defined as a disturbance in the prooxidant/antioxidant balance in favor of
the former and a loss of control over redox signaling processes, leading to potential …

The unregulated proliferative capacity of many tumors is dependent on dysfunctional
nutrient utilization and ROS (reactive oxygen species) signaling to sustain a deranged …