Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …

Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

[HTML][HTML] Origins of major human infectious diseases

ND Wolfe, CP Dunavan, J Diamond - Nature, 2007 - nature.com
Many of the major human infectious diseases, including some now confined to humans and
absent from animals, are 'new'ones that arose only after the origins of agriculture. Where did …

Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial

CC Iwuji, J Orne-Gliemann, J Larmarange… - The lancet HIV, 2018 - thelancet.com
Background Universal antiretroviral therapy (ART), as per the 2015 WHO recommendations,
might reduce population HIV incidence. We investigated the effect of universal test and treat …

Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: a meta-analysis of randomized controlled trials

JB Nachega, JJ Parienti, OA Uthman… - Clinical infectious …, 2014 - academic.oup.com
Background. Contemporary antiretroviral treatment regimens are simpler than in the past,
with lower pill burden and once-daily dosing frequency common. We performed a meta …

[HTML][HTML] Chronic kidney disease as a global public health problem: approaches and initiatives–a position statement from Kidney Disease Improving Global Outcomes

AS Levey, R Atkins, J Coresh, EP Cohen, AJ Collins… - Kidney international, 2007 - Elsevier
Chronic kidney disease (CKD) is increasingly recognized as a global public health problem.
There is now convincing evidence that CKD can be detected using simple laboratory tests …

[HTML][HTML] Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

Antiretroviral Therapy Cohort Collaboration - The Lancet, 2008 - Elsevier
BACKGROUND: Combination antiretroviral therapy has led to significant increases in
survival and quality of life, but at a population-level the effect on life expectancy is not well …

CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational …

C Mussini, P Lorenzini, A Cozzi-Lepri, G Lapadula… - The lancet HIV, 2015 - thelancet.com
Background In patients with HIV, immune reconstitution after antiretroviral therapy (ART) is
often incomplete. We assessed the probability of patients reaching a CD4/CD8 ratio of 1 or …

[图书][B] Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach-2010 revision

World Health Organization - 2010 - apps.who.int
ISBN 978 92 4 459976 1(NLM classification: WC 503.2)© всемирная организация
здравоохранения, 2010 г. все права защищены. публикации всемирной организации …

Cost-effectiveness of long-acting injectable HIV preexposure prophylaxis in the United States: a cost-effectiveness analysis

AM Neilan, RJ Landovitz, MH Le… - Annals of internal …, 2022 - acpjournals.org
Background: The HIV Prevention Trials Network (HPTN) 083 trial demonstrated the
superiority of long-acting injectable cabotegravir (CAB-LA) compared with oral emtricitabine …

Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a …

PE Sax, E DeJesus, A Mills, A Zolopa, C Cohen… - The Lancet, 2012 - thelancet.com
Background The integrase inhibitor elvitegravir (EVG) has been co-formulated with the
CYP3A4 inhibitor cobicistat (COBI), emtricitabine (FTC), and tenofovir disoproxil fumarate …