Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …

Parkinson's disease (PD) is a progressive neurodegenerative disease (NDD) caused by
dopaminergic neuron degeneration in the substantia nigra (SN). Orexin is a neuropeptide …

After a detailed description of orexins and their roles in sleep and other medical disorders,
we discuss here the current clinical evidence on the effects of dual (DORAs) or selective …

Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex
concerned in the wakefulness and excitement. This study aimed to review the possible …

Cognitive impairments and circadian rhythm disorders are the main clinical manifestations of
Alzheimer's disease (AD). Orexin has been reported as abnormally elevated in the …

Introduction Mounting evidence supports the existence of an important feedforward cycle
between sleep and neurodegeneration, wherein neurodegenerative diseases cause sleep …

Sleep disorders affect many people worldwide and can accompany neurodegenerative and
psychiatric diseases. Sleep may be altered before the clinical manifestations of some of …

Sleep and circadian rhythm disturbances are central features of many movement disorders,
exacerbating motor and non-motor symptoms and impairing quality of life. Understanding …

Insomnia-related sleep disruption can contribute to impaired learning and memory.
Treatment of insomnia should ideally improve the sleep profile while minimally affecting …

Orexinergic system consisting of orexins and orexin receptors plays an essential role in
regulating sleep–wake states, whereas sleep disruption is a common symptom of a number …